Single dose vaccination of the ASO3-adjuvanted A(H1N1)pdm09 monovalent vaccine in health care workers elicits homologous and cross-reactive cellular and humoral responses to H1N1 strains
Identifieur interne : 000521 ( Main/Exploration ); précédent : 000520; suivant : 000522Single dose vaccination of the ASO3-adjuvanted A(H1N1)pdm09 monovalent vaccine in health care workers elicits homologous and cross-reactive cellular and humoral responses to H1N1 strains
Auteurs : Sarah Lartey [Norvège] ; Rishi D. Pathirana [Norvège] ; Fan Zhou [Norvège] ; Sne Jul-Larsen [Norvège] ; Emanuele Montomoli [Italie] ; John Wood [Royaume-Uni] ; Rebecca Jane Cox [Norvège]Source :
- Human Vaccines & Immunotherapeutics [ 2164-5515 ] ; 2015.
Abstract
Healthcare workers (HCW) were prioritized for vaccination during the 2009 influenza A(H1N1)pdm09 pandemic. We conducted a clinical trial in October 2009 where 237 HCWs were immunized with a AS03-adjuvanted A(H1N1)pdm09 monovalent vaccine. In the current study, we analyzed the homologous and cross-reactive H1N1 humoral responses using prototype vaccine strains dating back to 1977 by the haemagglutinin inhibition (HI), single radial hemolysis SRH), antibody secreting cell (ASC) and memory B cell (MBC) assays. The cellular responses were assessed by interferon-γ (IFN-γ) ELISPOT and by intracellular staining (ICS) for the Th1 cytokines IFN-γ, interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α). All assays were performed using blood samples obtained prior to (day 0) and 7, 14 and 21 d post-pandemic vaccination, except for ASC (day 7) and ICS (days 0 and 21). Vaccination elicited rapid HI, SRH and ASC responses against A(H1N1)pdm09 which cross reacted with seasonal H1N1 strains. MBC responses were detected against the homologous and seasonal H1N1 strains before vaccination and were boosted 2 weeks post-vaccination. An increase in cellular responses as determined by IFN-γ ELISPOT and ICS were observed 1–3 weeks after vaccination. Collectively, our data show that the AS03-adjuvanted A(H1N1)pdm09 vaccine induced rapid cellular and humoral responses against the vaccine strain and the response cross-reacted against prototype H1N1 strains dating back to 1977.
Url:
DOI: 10.1080/21645515.2015.1048939
PubMed: 26009966
PubMed Central: 4514283
Affiliations:
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Pathirana</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>The Influenza Centre; Department of Clinical Science; University of Bergen</institution>; Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Department of Research & Development; Haukeland University Hospital</institution>; Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0003"><institution>K.G. Jebsen Centre for Influenza Vaccines; Department of Clinical Science; University of Bergen</institution>; Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, Fan" sort="Zhou, Fan" uniqKey="Zhou F" first="Fan" last="Zhou">Fan Zhou</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>The Influenza Centre; Department of Clinical Science; University of Bergen</institution>; Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0003"><institution>K.G. Jebsen Centre for Influenza Vaccines; Department of Clinical Science; University of Bergen</institution>; Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Jul Larsen, Sne" sort="Jul Larsen, Sne" uniqKey="Jul Larsen " first=" Sne" last="Jul-Larsen"> Sne Jul-Larsen</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>The Influenza Centre; Department of Clinical Science; University of Bergen</institution>; Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Department of Research & Development; Haukeland University Hospital</institution>; Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Montomoli, Emanuele" sort="Montomoli, Emanuele" uniqKey="Montomoli E" first="Emanuele" last="Montomoli">Emanuele Montomoli</name><affiliation wicri:level="1"><nlm:aff id="af0004"><institution>Department of Molecular and Developmental Medicine; University of Siena</institution>; Siena,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0005"><institution>VisMederi Life Sciences srl</institution>; Siena,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Wood, John" sort="Wood, John" uniqKey="Wood J" first="John" last="Wood">John Wood</name><affiliation wicri:level="1"><nlm:aff id="af0006"><institution>Formerly National Institute for Biological Standards and Control</institution>; South Mimms,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cox, Rebecca Jane" sort="Cox, Rebecca Jane" uniqKey="Cox R" first="Rebecca Jane" last="Cox">Rebecca Jane Cox</name><affiliation wicri:level="1"><nlm:aff id="af0001"><institution>The Influenza Centre; Department of Clinical Science; University of Bergen</institution>; Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0002"><institution>Department of Research & Development; Haukeland University Hospital</institution>; Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="af0003"><institution>K.G. Jebsen Centre for Influenza Vaccines; Department of Clinical Science; University of Bergen</institution>; Bergen,<country>Norway</country></nlm:aff><country xml:lang="fr">Norvège</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Human Vaccines & Immunotherapeutics</title><idno type="ISSN">2164-5515</idno><idno type="eISSN">2164-554X</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Healthcare workers (HCW) were prioritized for vaccination during the 2009 influenza A(H1N1)pdm09 pandemic. We conducted a clinical trial in October 2009 where 237 HCWs were immunized with a AS03-adjuvanted A(H1N1)pdm09 monovalent vaccine. In the current study, we analyzed the homologous and cross-reactive H1N1 humoral responses using prototype vaccine strains dating back to 1977 by the haemagglutinin inhibition (HI), single radial hemolysis SRH), antibody secreting cell (ASC) and memory B cell (MBC) assays. The cellular responses were assessed by interferon-γ (IFN-γ) ELISPOT and by intracellular staining (ICS) for the Th1 cytokines IFN-γ, interleukin-2 (IL-2) and tumor necrosis factor-α (TNF-α). All assays were performed using blood samples obtained prior to (day 0) and 7, 14 and 21 d post-pandemic vaccination, except for ASC (day 7) and ICS (days 0 and 21). Vaccination elicited rapid HI, SRH and ASC responses against A(H1N1)pdm09 which cross reacted with seasonal H1N1 strains. MBC responses were detected against the homologous and seasonal H1N1 strains before vaccination and were boosted 2 weeks post-vaccination. An increase in cellular responses as determined by IFN-γ ELISPOT and ICS were observed 1–3 weeks after vaccination. Collectively, our data show that the AS03-adjuvanted A(H1N1)pdm09 vaccine induced rapid cellular and humoral responses against the vaccine strain and the response cross-reacted against prototype H1N1 strains dating back to 1977.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Brockwell Staats, C" uniqKey="Brockwell Staats C">C Brockwell-Staats</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name sortKey="Webby, Rj" uniqKey="Webby R">RJ Webby</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hancock, K" uniqKey="Hancock K">K Hancock</name></author><author><name sortKey="Veguilla, V" uniqKey="Veguilla V">V Veguilla</name></author><author><name sortKey="Lu, X" uniqKey="Lu X">X Lu</name></author><author><name sortKey="Zhong, W" uniqKey="Zhong W">W Zhong</name></author><author><name sortKey="Butler, En" uniqKey="Butler E">EN 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Nason</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Italie</li><li>Norvège</li><li>Royaume-Uni</li></country></list><tree><country name="Norvège"><noRegion><name sortKey="Lartey, Sarah" sort="Lartey, Sarah" uniqKey="Lartey S" first="Sarah" last="Lartey">Sarah Lartey</name></noRegion><name sortKey="Cox, Rebecca Jane" sort="Cox, Rebecca Jane" uniqKey="Cox R" first="Rebecca Jane" last="Cox">Rebecca Jane Cox</name><name sortKey="Cox, Rebecca Jane" sort="Cox, Rebecca Jane" uniqKey="Cox R" first="Rebecca Jane" last="Cox">Rebecca Jane Cox</name><name sortKey="Cox, Rebecca Jane" sort="Cox, Rebecca Jane" uniqKey="Cox R" first="Rebecca Jane" last="Cox">Rebecca Jane Cox</name><name sortKey="Jul Larsen, Sne" sort="Jul Larsen, Sne" uniqKey="Jul Larsen " first=" Sne" last="Jul-Larsen"> Sne Jul-Larsen</name><name sortKey="Jul Larsen, Sne" sort="Jul Larsen, Sne" uniqKey="Jul Larsen " first=" Sne" last="Jul-Larsen"> Sne Jul-Larsen</name><name sortKey="Lartey, Sarah" sort="Lartey, Sarah" uniqKey="Lartey S" first="Sarah" last="Lartey">Sarah Lartey</name><name sortKey="Pathirana, Rishi D" sort="Pathirana, Rishi D" uniqKey="Pathirana R" first="Rishi D" last="Pathirana">Rishi D. Pathirana</name><name sortKey="Pathirana, Rishi D" sort="Pathirana, Rishi D" uniqKey="Pathirana R" first="Rishi D" last="Pathirana">Rishi D. Pathirana</name><name sortKey="Pathirana, Rishi D" sort="Pathirana, Rishi D" uniqKey="Pathirana R" first="Rishi D" last="Pathirana">Rishi D. Pathirana</name><name sortKey="Zhou, Fan" sort="Zhou, Fan" uniqKey="Zhou F" first="Fan" last="Zhou">Fan Zhou</name><name sortKey="Zhou, Fan" sort="Zhou, Fan" uniqKey="Zhou F" first="Fan" last="Zhou">Fan Zhou</name></country><country name="Italie"><noRegion><name sortKey="Montomoli, Emanuele" sort="Montomoli, Emanuele" uniqKey="Montomoli E" first="Emanuele" last="Montomoli">Emanuele Montomoli</name></noRegion><name sortKey="Montomoli, Emanuele" sort="Montomoli, Emanuele" uniqKey="Montomoli E" first="Emanuele" last="Montomoli">Emanuele Montomoli</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Wood, John" sort="Wood, John" uniqKey="Wood J" first="John" last="Wood">John Wood</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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